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Chunk #50 — THEORETICAL DERIVATIONS — IMPACT OF LD ON DISEASE PARAMETERS — General model

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Disease model distortion in association studies.
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The figures also show the effective additive parameters, and , calculated using logistic regression as described above. Thus, in these figures we have plotted the exact values for all parameters, rather than approximations based on Equations (4) and (5). We can see that the approximations accurately describe the observed behavior, with the dominance effect decaying faster than the additive effects, approximately quadratically vs. linearly.