and pharmacological studies demonstrated a role of DISC1 in regulating development of post-mitotic newborn neurons through mTOR (Figure 7). Whether GSK3β plays a cell autonomous role in regulating development of newborn neurons in the adult brain remains to be fully characterized. The distinct functions and signaling mechanisms of DISC1 at different cellular stages further substantiate the notion that DISC1 regulates multiple aspects of neural development in a temporal and cell-type specific manner.
