Drug-drug interactions within DrugBank have been greatly improved through better curator training, the use of SOPs and the use of drug categories to generate interactions. In addition, our regular monitoring of the US, Canada and EU for labeling updates now includes new drug–drug and drug–food interactions, ensuring better drug interaction coverage. In addition to these efforts, curators have also undertaken several large-scale projects that either directly or indirectly improved the quality of our interactions data. One such initiative (conducted in 2020–2021) addressed the accuracy of therapeutic categorizations, some of which are used to generate drug–drug interactions. This included an initial review of roughly 1200 therapeutic drug-category relations associated to 819 distinct drugs. After further review, a total of 901 relations for drugs were changed to no longer be therapeutic and were instead replaced by a different drug-category therapeutic relation. Currently, 151 therapeutic categories generate drug–drug interactions within DrugBank. As such, the improved accuracy of their drug membership represents a substantial improvement to the overall quality of DrugBank's drug interaction dataset.
