The majority of studies have focused on gamma/theta CFC, but coupling between other frequency bands has been shown to play an important role for coordination in perception, consciousness, and working memory (Palva and Palva, 2007) and has been associated with neuropsychiatric symptoms (Miskovic et al., 2010), which are also prevalent in patients with AD. However, we did not find any significant changes for CFC between AD, MCI, and HC in the other frequency bands. The largest difference was found for gamma/alpha coupling (p-value = 0.076, F-value = 2.678). The lack of findings suggests that gamma/theta coupling may be the most important measure in AD. However, larger studies are needed to fully understand the pathophysiological role of CFC in AD.
