when testing in the same sample with similar phenotype (rg 1.07, SE=0.0343) between MDD and SR-Depression within MVP), or between the somewhat smaller FinnGen sample and the large PGC/UKB broad depression (rg 1.21, SE=0.25) and 23andMe (rg=1.07, SE=0.21) samples. LD-intercept (1.03, SE 0.011) and attenuation ratio (0.0297, SE 0.011) of the LD score regression revealed minimal evidence for inflation or confounding, with 97% of inflation observed due to high polygenicity of depression.
