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Chunk #38 — DISCUSSION

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Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.
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In our SZ group, the AD value of callosal fibers in the orbital frontal segment significantly associated with attention scores, and the AD value of this tract was significantly increased compared to the HC group. Histological information indicates the AD assesses axonal function (Mac Donald, Dikranian, Bayly, Holtzman, & Brody, 2007). Some previous studies reported no significant difference in AD value of the CC between patients with schizophrenia and healthy controls (Hummer et al., 2016; Kochunov et al., 2014; Liu et al., 2013; Spalletta et al., 2015; Whitford et al., 2010). The largest coordinated meta‐analysis on DTI data showed significantly higher AD value in schizophrenia patients compared with healthy controls in the fornix but showed no significant differences in the AD value in the CC (Kelly et al., 2018). To our knowledge, there is no study reported relationship of AD value with cognitive function in schizophrenia. The studies on patients with essential tremor showed positive correlation between the AD value and cognitive function (Julian et al., 2017; Bhalsing et al., 2015). Same as these previous studies on essential tremor, our