Based on our prior study (21), we predicted that patients with greater alpha than expected for controls would respond well to SRI treatment, whereas those with less alpha would not. This prediction was tested by using the median of condition-dependent alpha for healthy controls (eyes-closed minus eyes-open, averaged across low- and high-alpha factors) to classify patients as having greater alpha (predicted to be responders) or less alpha (predicted nonresponders) than healthy controls. The capacity of condition-dependent alpha to predict treatment outcome was also explored using logistic regression. The association between condition-dependent alpha and measures related to depression (e.g., BDI and HAM-D) were examined using product-moment correlations.
