Chunk #57 — 6.0 How Do Electrophysiological Endophenotypes Compare with Other Quantitative Traits? — 6.2 Is the “genetic architecture” of endophenotypes different from that of other phenotypes?
of 80% from twin and family studies, this was also much greater than the amount of variance in height accounted for by GWAS of tens of thousands of subjects, which at the time of this 2010 publication had identified approximately 50 loci accounting for about 5% of the variance in height in total. The difference between the variance accounted for by individual variants (5% in the case of height) and phenotypic heritability is called “missing heritability” (Manolio et al., 2009). The GREML analysis of height indicated that a substantial fraction of the total heritability in height was in fact captured by some unknown but presumably very large number of genotyped SNPs, indicating that much of the variance in height is therefore due to common SNPs.
