Two missense variants in ALDH1B1 are predicted to be damaging (Way et al., 2017). The Ala86Val variant (ALDH1B1*2; rs2228093) was inactive when expressed in vitro (Jackson et al., 2015). In a Danish allergy cohort, rs2228093 was correlated with fewer drinks/week and alcohol-induced hypersensitivity (rash, itch), although rs2073478, in LD with it, was not (Husemoen et al., 2008, Linneberg et al., 2010). Rs2073478 (Arg107Leu) was associated with heavy drinking in Inuit in Greenland (Bjerregaard et al., 2014). However, neither rs2228093 nor rs2073478 was associated with alcohol dependence in a larger study of British individuals (Way et al., 2017).
