user interface components. To build the locus plot (Supplemental Figure S2) for example, we use a canvas element as it is not possible to accomplish the visualisation with regular DOM nodes. To ensure global access, Open Targets Genetics is deployed on GCP across three different regions: in Europe (Belgium zone), United States (South Carolina zone) and Asia (Tokyo zone) (Supplemental Figure S1). Each regional deployment is the same and globally balanced. All code is open source and accessible in the repositories listed in Supplementary Table S1.