rs8052287. We observed putative gene-environment effects in rs8052287 (BF > 0) for OD criterion counts (BF = 12.2), CoD criterion counts (BF = 12.1), ND criterion counts (BF = 9.2), and co-occurrence of multiple SD diagnoses (BF = 2.1). We found that rs8052287 was associated with the transcriptomic regulation of 26 genes in 30 different tissues (Supplemental Table 4). Considering brain tissues, we observed that rs8052287 is associated with RANBP10 in the cerebellum (p = 6.2 × 10−18), cortex (p = 4.3 × 10−12), frontal cortex (BA9; p = 4.9 × 10−9), cerebellar hemisphere (p = 8.9 × 10−9), caudate (p = 4.8 × 10−7), and nucleus accumbens (p = 2.5 × 10−5). Rs8052287 is also a splicing quantitative trait locus for CARMIL2 in the frontal cortex (BA9; p = 1.2 × 10−6). Considering data available from the GWAS atlas, we observed 20 significant associations that survived phenome-wide multiple testing correction (Supplemental Table 5), including anthropometric traits (e.g., height p = 8.30 × 10−22), male hair loss pattern (p = 1.11 × 10−10), hypothyroidism (p = 5.97 × 10−7), and several hematological parameters (e.g., mean corpuscular hemoglobin p = 4.74 × 10−7). The same associations were also observed in the
