In the singletons sample, the most significant associations with dependence were found for three SNPs in the CHRNB3 gene (rs7004381, rs4950, and rs13280604). Evidence for an association with the CHRNA6 gene was less consistent in the singletons (Table 7). However, although the sample size for the quit attempt variable in singletons was quite small, directional trends emerged that were consistent with findings in the families. The consistency of the results across this region further supports the findings in the larger set of families.
