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Chunk #13 — 2. Techniques to investigate networks integrity — 2.4 Network organization

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Functional network disruption in the degenerative dementias.
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Increasing evidence suggests that functional and structural network properties are related to development,41 age and cognition.42-44 Older (mean age of 67) vs. Young (mean age of 24) adults show a distinct modular organization of the brain, the former with greater connectivity between posterior and central regions, and the latter showing higher connectivity between fronto-cingulo-parietal modules.42 In addition, IQ score has been negatively correlated with global functional connectivity (characteristic path length) in young adults,43 and the structural efficiency of networks has been negatively associated with age, and positively correlated with processing speed, visuospatial and executive functions.44