that there are genotypic and phenotypic differences between the line-pairs suggests that common gene networks/pathways may be identified across the line-pairs rather than common individual genes. The study revealed that no single gene was significant across all five line-pairs, although 22 genes differed significantly in the same direction across three or four of the line-pairs. Moreover, analyses using Gene Ontology and Ingenuity Pathway information revealed significant categories and networks for up to three, but not more, of the line-pairs. In general, the biological systems identified included transcription, synaptic function, intracellular signaling and protection against oxidative stress with the dopamine and glutamate neurotransmitter systems implicated as well (McBride et al., 2012).
