as compared to Asn40 homozygotes (Oslin et al., 2003). As these findings emerged, influential reviews have highlighted the potential clinical utility of this polymorphism as a pharmacogenetic predictor of response to naltrexone, 1 of only 3 pharmacotherapies approved by the FDA for the treatment of alcoholism (Oroszi and Goldman, 2004; Oslin et al., 2006). Importantly, the Asn40Asp SNP was advanced as an a priori genetic moderator of clinical response to naltrexone in the Combining Medications and Behavioral Interventions for Alcoholism (COMBINE) Study, a large multisite trial allowing for a retrospective analysis of clinically meaningful pharmacogenetic effects (Goldman et al., 2005).
