Chunk #54 — 3. Results — 3.2. Electrophysiologic data — 3.2.2. Stimulus-locked PCA component waveforms and topographies

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Stimulus- and response-locked neuronal generator patterns of auditory and visual word recognition memory in schizophrenia.

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As the present CSD-PCA solutions were entirely consistent with those of the combined stimulus-and response-locked analyses for the larger sample of healthy adults (Kayser et al., 2007), the stimulus-locked analysis focused on factors summarizing stimulus-driven, modality-specific CSD activity preceding the response.4 Auditory CSD factors corresponded to N1 sink (peak latency 110 ms; left mid-central maximum; 1.7% explained variance), P2 source (210 ms; frontocentral maximum; 3.9%), N2 sink (385 ms; vertex maximum; 13.6%), and P3 source (685 ms; lateral-parietal sources paired with lateral-frontal sinks; 28.1%; Figure 4C). Similarly, visual CSD factors corresponded to N1 sink (130 ms; left lateral inferior-parietal maximum; 2.8%), P2 source (195 ms; occipital maximum with lateral-parietal sinks; 6.0%), N2 sink (270 ms; mid-frontocentral maximum with medial-parietal sources; 3.8%), and P3 source (490 ms; mid-parietal and frontopolar sources paired with lateral-frontal sinks; 21.1%; Figure 5D).