Among European-American children, the effect of intervention was moderated by variation in the glucocorticoid receptor gene NR3C1; the Fast Track intervention was more efficacious in preventing externalizing psychopathology among carriers of the rs10482672 “A” allele (δ=−0.520, p= 0.00006). Among carriers of the “A” allele, 18 percent of treated children as compared to 75 percent of control children manifested any externalizing psychopathology at age 25 follow-up. In contrast, for non-carriers of the “A” allele, 56 percent of treated children and 57 percent of control children manifested externalizing psychopathology at follow-up (Figure 2). The remaining 9 SNPs did not show evidence of moderating Fast Track intervention response. Among African-American children, there was no evidence that any of the measured SNPs moderated Fast Track intervention effects. Full results for European-American and African-American samples for all ten tested SNPs are reported in Appendix Tables A1 and A2xi.
