For Ca-HL samples in Yale-Penn cohorts, there were 1092 Yale-Penn 1 EAs (cases = 51 and controls = 1041), 825 Yale-Penn 2 EAs (cases = 40 and controls = 785), 1610 Yale-Penn 1 AAs (cases = 149 and controls = 1461), and 758 Yale-Penn 2 AAs (cases = 71 and controls = 687). Meanwhile, for replication samples from COGA, 2374 EAs (cases = 256 and controls = 2118) and 1256 (cases = 142 and controls = 1114) AAs had genotypic data and reported long-term use of cannabis.