This is the first prospective cohort investigation of the association between CYP2A6 genotype and quitting smoking in adolescence, and showed that CYP2A6 slow nicotine metabolism is associated with an increased likelihood of quitting smoking. This is similar to the effect of CYP2A6 slow metabolism on increasing quit rates in adults [2], providing further evidence that slow nicotine metabolizers have better quit rates in general.
