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Chunk #44 — Online Methods — Statistical analyses for differential methylation by development

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Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex.
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CGDMRs were obtained from Lister et al16 which were relative to genome build hg18. We used the corresponding hg18-based probe coordinates from the Illumina 450k manifest file to perform the overlaps between the microarray and WGBS data at the CpG and DMR level, and then used the liftOver tool to map from hg19 to hg18 at the block level (since 450k probes are collapsed to probe groups and given an average coordinate)50.