our cohorts; thus, we might expect to replicate ∼80% of genuine associations. Although this is likely to be something of an overestimate because of OR overestimation due to the “winner’s curse” [20], the minimum OR in the original reports was 25 [10], [16]), and even for much lower effect sizes with OR≥5 we would nevertheless expect to detect 62% of associations (71% of those with OR≥10).
