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Chunk #40 — Rare and Common Variants

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The genetic basis of addictive disorders.
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Rare genetic variants relevant to addiction have been found within the serotonin receptor 2B gene (HTR2B) and MAOA, and several of the functional CYP26 alleles are also rare or uncommon. Both HTR2B and MAOA influence impulsivity and behavioral control and findings for these genes in humans remarkably parallel animal models.