T-cell maturation and immunity. Several marks successfully recovered these biological groupings when evaluated in their relevant chromatin states (Fig. S8), including H3K4me1 in TssA, H3K27me3 in ReprPC state, and H3K27ac in Enh states, suggesting that the signal of each mark in relevant chromatin states is highly indicative of cell type and tissue identity. These alternative clusterings also showed some differences; for example, H3K4me3 in TssA states grouped several fetal samples together with each other, in a cluster sister to ESCs and iPSCs, rather than in separate tissue groups.
