In summary, we have presented results from the first large GWAS of reexperiencing, a quantitative trait highly characteristic of PTSD. Significant markers identified correspond to genes that influence corticosteroid and steroid function (e.g. CRHR1 and HSD17B11), and have also been associated with schizophrenia (TCF4 and MAD1L1), and other psychiatric traits (the latter two having been previously implicated for pleiotropic effects on psychiatric traits). Gene-based analyses identified numerous additional associated loci. At the cell type level, we found the transcriptomic profile of medium spiny neurons (located in the striatum) to be associated with reexperiencing symptoms. There were highly significant genetic correlation results with numerous mental and physical health traits. Our results confirm prior biological knowledge regarding relationships with steroid response, and suggest new biological relationships with implications for treatment response and precision medicine. They also demonstrate the immediate utility of the MVP sample for disorders prevalent in US veterans.
