Chunk #29 — Online Methods — Statistics — Identification of genes with differential expression levels between cannabis users and non-users

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GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.

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We used the GTExPortal (https://www.gtexportal.org/home/; GTEx Analysis Release V7)58 to obtain gene expression levels of CADM2 across tissues. We used the same portal to plot a multi-tissue eQTL comparison of the top SNP rs2875907. The multi-tissue eQTL plot shows both the single-tissue eQTL p-value and the multi-tissue posterior probability from METASOFT59.