There are some limitations in the estimation of Smokescreen array performance. It should be noted that the coverage is an estimate based on the design of the array. The realized coverage is not yet computable as the validation of markers is ongoing. Approximately 12 % of SNPs on the array are too rare to be observed with the current sample size. Additional samples will improve genotype clustering of rare SNPs or SNPs with low quality metrics. Some pilot samples derived from saliva were genotyped, but the sample size was not sufficient for estimating performances on these samples separately. In general, we recommend saliva samples to be collected using kits with preservatives. Laboratories familiar with Axiom Arrays should assess the quality of salivary samples with suspect collection or storage method prior to genotyping.
