In addition to the aforementioned trans-activating events, CREM promoter P1 is subject to epigenetic modifications, which regulate gene expression. CpG methylation influences the tissue-specific regulation of CREM in human T lymphocytes. Specifically, effector memory CD4+ T lymphocytes and T cells from SLE patients exhibit significantly reduced meCpG levels at CREM P1, contributing to enhanced CREMα mRNA expression [34].
