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Chunk #17 — MATERIALS AND METHODS — Statistical Analyses

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H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence.
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Analyses were performed using the SAS statistical software package version 9.1 (SAS Institute, 2004). The primary analyses examine whether G × E interactions involving the H2 haplotype and a history of CSA are protective against alcohol consumption and DSM-IV alcohol dependence. For linear regression analyses, the SurveyReg Procedure was used to control for inclusion of data from multiple members of families. For logistic regression analyses, the SurveyLogistic Procedure provided similar control. We performed T-tests to determine if mean ACFS differed by CSA status when controlling for gender and genotype. A significance threshold of alpha=0.05 was used for all analyses.