The subjects included in the initial analysis, examining the independent and interactive effects of smoking, obesity, and childhood conduct problems, were 218 women. They were 18–66 years of age, of mixed race and ethnicity, and drawn from separate families. For the secondary analysis of the effects of the GABRA2 genotype and obesity, 110 women, 19–65 years of age, from separate families were included. The secondary analysis was limited to European Americans to eliminate admixture artifact.