Chunk #12 — RESULTS — Genome-wide association study of DSM-defined nicotine dependence

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Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

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In the MAGMA gene-based analysis of the European ancestry data, three genes were significant after multiple testing corrections: CHRNA5, CHRNA3, and IREB2 (Supplemental Table 4). Three gene-sets were significantly associated: