Exercise may impact oxidative stress. This would have clear implications for mood disorders in which there are increases in inflammation and oxidative stress [116, 117, 120]. Specifically, Agarwal et al. found that 16 weeks of moderate-intensity exercise decreased oxidative stress and reduced proinflammatory cytokines in control and hypertensive rat models [121]. However, other studies have found increases in oxidative stress after exercise, particularly in higher intensity exercise [122, 123]. Thus, further research should be conducted to explore the relationship between exercise and oxidative stress in individuals with MDD or bipolar disorder [27, 32, 88, 89, 120, 124].
