The MRI scans were performed at the University of Pittsburgh Medical Center (UPMC) Magnetic Resonance Research Center (MRRC) using a 3T Siemens Trio scanner (Siemens Medical Systems, Ehrlangen, Germany) equipped with a fast gradient system for echoplanar imaging. A standard radio frequency head coil was used with foam padding to restrict head motion. A 7-min 3D T1-weighted Magnetization Prepared Rapid Gradient Echo Imaging (MPRAGE) sequence (TR=2300ms, TE=2.98 ms, FA=9°, field of view FOV=240mm, acquisition matrix = 240 × 256, in-plane resolution 1.0×1.0 mm2, yielding 160 transversal slices with a thickness of 1.2mm) was used to acquire a high-resolution anatomical scan for VBM analysis.
