For the 16 SNPs identified with combined P < 5 ×10-6 (Table 1), there was, in the FINRISK97 panel, no evidence of departure from an additive genetic model (P > 0.05 for likelihood ratio test of additive versus unconstrained two degree-of-freedom test), no significant difference in effect size between males and females (P > 0.05), and no strong epistatic interactions between loci (the most significant interaction was observed between SNP rs1492820 and SNP rs10946808 (P = 0.001), which is not significant after correcting for the 120 pairwise tests of interaction done).
