over our three planned cohorts. The DNA samples are currently being genotyped on the Affymetrix Biobank Version 2 Array, which contains both rare variation (exome and structural variation), as well as an imputation GWAS grid. These data will be informative for gene identification for quantitative alcohol use and mental health outcomes (and other behavioral traits that were collected, such as personality), and can be combined with other samples to contribute to meta-analyses. In addition, polygenic risk scores can be created in the sample based on results from meta-analyses for a variety of behavioral health outcomes to study how these genetic risk scores impact outcomes in the college students, and interact with other environmental and social factors. The longitudinal nature of the data collection will allow us to study how genetic and environmental influences impact trajectories of substance use and mental health across time. In addition, students were informed that the data they provided could be used to select students to invite them to participate in future spin-off projects. In this way, we have created a large database from which individuals can be selected either based on phenotypic or genotypic data for more intensive studies. For example, we plan to invite
