We applied our 3-stage approach to construct two GRSs for obesity. First, we considered only GWAS published in print or online through December 31, 2008. We chose these GWAS because they were used in previous research that created “top-hits” and “best-guess” obesity GRSs. Thus, we used these GWAS to construct a GRS using our 3-stage approach and compared it to two published GRSs 29,30. Second, we considered all GWAS published through December 31, 2010. We applied our 3-stage approach to results from the full set of GWAS and compared the resulting GRS to a top-hits GRS generated from the largest meta-analysis of BMI GWAS published to date 31 and to a best-guess GRS generated from the full set of obesity-associated SNPs reported in the National Human Genome Research Institute (NHGRI) GWAS Catalog 18. The derivation of the GRS using the 3-stage approach is described in detail in the supplemental material. Analyses described in the supplemental material revealed that the 3-stage approach created GRSs that were at least as predictive of BMI and obesity as GRSs created with the top-hits and
