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Chunk #57 — Conclusions

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Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.
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Our combined data implicate COL6A3, KLF12, RYR3 and LOC339975 in response to ethanol across multiple species and/or AD risk in humans. Our data are also consistent with prior work implicating remodeling of the ECM (COL6A3), regulation of ethanol-responsive genes (KLF12), and regulation of intracellular calcium release (RYR3) in response to ethanol.