Chunk #53 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
8 re-examinations, one approximately every 4 years. Starting at the 2nd Offspring examination, participants were questioned regarding any subjective memory complaints and since the 5th Offspring examination participants have been administered the MMSE at each visit. In addition concurrent with the 7th and 8th Offspring examinations (between 1999 and 2004 and then again between 2005 and 2009) surviving Original cohort and all eligible and consenting Offspring participants have undergone volumetric brain MRI and neuropsychological testing60,61. The neuropsychological test battery included the Reading subtest of the Wide Range Achievement Test (WRAT-3), the Logical Memory and the Paired Associates Learning tests from the Wechsler Memory Scale, the Visual Reproduction and Hooper Visual Organization Tests, Trails A and B, the Similarities subtest from the Wechsler Adult Intelligence test, the 30-iterm version of the Boston Naming Test and at the second assessment only, the Digit Span, Controlled Word Association and Clock Drawing Tests. Offspring participants suspected to have cognitive impairment based on their MMSE scores, participant, family or physician referral, hospital records or performance in the neuropsychological test battery described above were referred for more detailed neuropsychological and neurological evaluation.
