We determined whether variants that were genome-wide associated with fast beta EEG were also associated with DSM-IV AD44 in the discovery sample (2242 individuals from 480 families (Table 1)). Non-drinkers, those aged <18 years and unaffected individuals with 2+ SUD criteria were excluded. Analyses were performed using SAS Version 9.4 (SAS Institute (http://search.ebscohost.com/login.aspx?direct=true&db=plh&AN=101476231&site=eds-live)). Logistic regression models were adjusted for age, sex, relatedness and PC1–PC10. Given that a single phenotype was tested, we examined association with all fast beta EEG genome-wide significant SNPs. Individual P-values were adjusted using the Pnorm procedure,45 which accounts for both the LD structure of the SNPs, and the sampling of relatives. Pnorm uses the multivariate normal distribution approximation to evaluate the significance of each test adjusting for simultaneous testing.
