Although many molecular targets of eCBs have been described, the primary targets of these compounds are the cannabinoid receptor types 1 and 2 (CB1 and CB2 respectively). eCBs are produced by almost all cell types that have been examined, and the CB1 and CB2 receptors are present in both nervous and peripheral tissues. Here we will primarily focus on CB1 receptor-mediated eCB signaling as this is most heavily implicated in the synaptic and behavioral functions of cannabinoids (Chevaleyre et al., 2006; Hashimotodani et al., 2007; Heifets and Castillo, 2009; Kano et al., 2009).
