In this study population, no increased risk of lung cancer was associated with these SNPs among never smokers. Similar results were shown in one of the replication studies presented by Amos et al.6 and an additional replication population from Texas,18 but in the study of Hung et al.7 lung cancer in never smokers was associated with rs8034191 genotype. In the study conducted in Japan, a haplotype including rs8034191 and rs1051730 in combination with rs16969968 was associated with lung cancer risk both in smokers and non-smokers.16 The numbers of never smokers with lung cancer included in any of these studies are relatively small and this is an area that deserves more attention in future studies.
