We performed two different cell-type-specific analyses: an analysis of 220 individual cell-type-specific annotations, and an analysis of 10 cell-type groups (see Overview of Methods). For the analysis of single cell types, we assessed statistical significance at the 0.05 level after Bonferroni correction for 220×17=3,740 hypotheses tested, and for the cell-type group analysis, we corrected for 10×17=170 hypotheses tested. This is conservative, since the 220 cell-type-specific annotations are not independent, and neither are the 10 cell-type group annotations. We also report results with false discovery rate (FDR) < 0.05, computed over 220 cell types for each trait for the cell-type specific analysis, and over all cell-type groups and traits for the cell-type group analysis. For 15 of the 17 traits, the top cell type passed an FDR threshold of 0.05, while for 16 of the 17 traits (all traits except anorexia), the top cell-type group passed an FDR threshold of 0.05. The top cell type for each trait is displayed in Table 1, with additional top cell types reported in Supplementary Table 7. Cell-type group results for the 11 traits with
