Neurobiological models of obsessive-compulsive disorder (OCD) postulate the involvement of several parallel, partly segregated, cortico-striato-thalamo-cortical circuits.1,2,3 Among these, a ventral affective circuit, which includes the orbitofrontal cortex, nucleus accumbens, and thalamus, is thought to be involved in reward processing.1,2,3 Consequently, neurobiological models predict an association of OCD with substance use disorders (SUDs) and behavioral addictions,4,5,6 possibly reflecting a shared compulsivity endophenotype.7,8,9 However, empirical support for this predictive model has been mixed.
