his simulations). The possibilities for loosely defined, indirect replications are even more extensive in cG×E research than in candidate gene main effect research because of the additional environmental and moderator predictors. Thus, we believe it is important that only direct replications are considered when gauging the validity of the original cG×E finding (see also Chanock et al. [37]). Once an interaction is supported by direct replications, indirect replications can gauge the generalizibilty of the original finding, but until then they should be considered novel reports, not replications.
