Because the distribution of alcohol into fat is almost negligible (97), the fat-to-lean tissue ratio plays a key role in the volume of distribution of alcohol (Vd). Therefore, women, who generally have a higher percentage of body fat than men, reach a higher peak BAC when both sexes receive the same intravenous dose of alcohol per kilogram of body weight (103). Similarly, with aging, people tend to lose muscle mass and gain fat, which helps explain, at least in part, why men above 60 years of age reach higher peak BAC when ingesting the same alcohol dose per kilogram of body weight than younger men (104).
