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Chunk #28 — Discussion

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Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.
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Genetic correlations with available GWAS summary statistics from 1,457 traits were conducted to assess overlap with other traits. There was high genetic correlation between our MDD-META meta-analysis and depression medication prescription in FinnGen (rg=0.89). This could be of value in evaluating depression phenotypes from large cohorts with access to linked pharmacy records; anti-depressant medication prescription may be a viable proxy phenotype for depression diagnosis.