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Chunk #9 — Materials and methods — SNP assignment

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Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
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Where a SNP lay within the boundaries of more than one gene, that SNP was arbitrarily assigned to the gene which included the lowest base number on the chromosome assembly. Arbitrary decisions of this nature and errors in SNP/gene assignment present in the databases have no biological validity, and therefore it is anticipated they will generally generate noise and reduce the power. In total, we retained 145,344 (38.5% of the total) SNPs which annotated 13,098 unique genes (1 - 799 SNPs per gene).