Chunk #9 — Results — Meta-analyses of CHARGE genome-wide association results

Source

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

Embedded

yes

Text

To evaluate whether other loci may also influence pulmonary function, we created Q-Q plots for FEV1/FVC and FEV1 among all participants after removing SNPs (1,862 for FEV1/FVC and 284 for FEV1) at or close to genome-wide significance and nearby SNPs correlated at r2>0.2 with the top SNP for each locus. The resulting Q-Q plots show some excess of small P values for FEV1/FVC (Supplementary Fig. 4a) and FEV1 (Supplementary Fig. 4b).