In this study, we adopted a PHeWAS approach, meaning that we tested the association between CADM2 and all risk behavior and self‐control measures that were available in the datasets. In order to provide an overview of all measures, we grouped them into six categories: lifetime experience with substance use (regarding tobacco, cannabis, and other substances), age at initiation of substance use (regarding alcohol, tobacco, cannabis, and other substances), average substance use level (regarding alcohol and tobacco), regular substance (ab)use (including regular alcohol, tobacco, and cannabis use and any behavioral/substance addiction), sexual risk behavior (including the number of sexual partners, sexual risk‐taking, and age at first sexual intercourse), and self‐control (including disinhibition, sensation seeking, risk‐taking proneness, and symptoms of ADHD). Variables with a total N of < 1,000 were excluded as they could not be analyzed due to a lack of statistical power. Preprocessing of the data included combining measures (e.g., across different waves), removing outliers, and excluding inconsistent or invalid response patterns. An overview of all 23 outcome measures included can be found in Table 1. More detailed information about the (cleaning and combining of the) measures is given in Table S2.
