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Chunk #23 — Discussion

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
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Our implication of genes of potential functional relevance to the 97 signals was based on gene expression data (eQTL) and associated deleterious variants within a gene. Although eQTL evidence currently gives the best in silico indication of which gene (or genes) might be functionally relevant to a signal, conclusive evidence for a causal relationship between SNP genotype and gene expression can only be obtained through direct molecular experiments.