Depue (1995) summarized the interaction of low levels of 5HT and high levels of DA as involving (a) exaggerated response to stimulus conditions eliciting DA facilitation; (b) greater sensitivity to current reward stimuli; (c) increased pursuit of sanctuary from stress and conflict, including both active avoidance and impulsive acts; (d) impulsive behavior from over-reactivity to reward plus active avoidance; (e) frequent, varied attempts to experience the increased magnitude and frequency of DA-related reward, such as through drugs and tobacco, and (f) irritability-hypersensitivity.
